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Publications
Alkaline Phosphatase Activity
ATP Assay
ATP Cell Proliferation Assay
ATP Cell Viability Assay
Bacteria Detection (ATP)
Beta Galaktosidase Assay
Bioluminescence
Ca++/Aequorin
CALUX Assay
Caspase Assay
Fe-Bioreporter Assay
Gaussia Reporter Assay
Immunoassay
Luciferase Reporter Assay
Luciferase Research
Lucigenin-enhanced chemiluminescence (ROS)
Miscellaneous
SEAP Reporter Assay
Toxicity and Mutagenictiy
Tumor Chemosensitivity Assay
Alkaline Phosphatase Activity Assay
| The Journal of Neuroscience, February 4, 2004, 24(5):1101-1112 |
| Orion - Nuclear Factor E2-Related Factor 2-Dependent Antioxidant Response Element Activation by tert-Butylhydroquinone and Sulforaphane Occurring Preferentially in Astrocytes Conditions Neurons against Oxidative Insult |
| Andrew D. Kraft, Delinda A. Johnson, and Jeffrey A. Johnson |
ATP Assay
| Yuan He, Kar Wah Leung, Ye-Hong Zhuo, Jian Ge |
| Orion - Pro370Leu mutant myocilin impairs mitochondrial functions in human trabecular meshwork cells |
| Molecular Vision 2009 15:815-825 |
| Mostafa E. Rateb, Wael E. Houssen, Marc Schumacher, William T. A. Harrison, Marc Diederich, Rainer Ebel and Marcel Jaspars |
| Orion - Bioactive Diterpene Derivatives from the Marine Sponge Spongionella sp. |
| J. Nat. Prod., 2009, 72 (8), pp 1471?1476 |
| Nicholas Bandarenko, Jose Cancelas, Edward L. Snyder, Shauna N. Hay, Neeta Rugg, Tammy Corda, Amy D. Joines, Jennifer F. Gormas, Gayle P. Pratt, Richard Kowalsky, Michael Rose, Leslie Rose, Jim Foley, and Mark A. Popovsky |
| Orion - Successful in vivo recovery and extended storage of additive solution (AS)-5 red blood cells after deglycerolization and resuspension in AS-3 for 15 days with an automated closed system |
| Transfusion Volume 47 Issue 4, Pages 680 - 686 |
| Frank Pillekampa, Michael Reppel, Olga Rubenchyk, Kurt Pfannkuche, Matthias Matzkies, Wilhelm Bloch, Narayanswami Sreeram, Konrad Brockmeier, Juergen Hescheler |
| Sirius - Force measurements of human embryonic stem cell-derived cardiomyocytes in an in vitro transplantation model |
| Stem Cells Vol. 25 No. 1 January 2007, pp. 174 -180 |
| Sabine Hombach-Klonisch, Joanna Bialek, Bogusz Trojanowicz, Ekkehard Weber, Hans-Juergen Holzhausen, Josh D. Silvertown, Alastair J. Summerlee, Henning Dralle, Cuong Hoang-Vu and Thomas Klonisch |
| Sirius - Relaxin Enhances the Oncogenic Potential of Human Thyroid Carcinoma Cells |
| American Journal of Pathology. 2006, 169:617-632 |
| Jose Gonzalez-Alonso, Stefan P. Mortensen, Ellen A. Dawson, Niels H. Secher and Rasmus Damsgaard |
| Orion - Erythrocytes and the regulation of human skeletal muscle blood flow and oxygen delivery: role of erythrocyte count and oxygenation state of haemoglobin |
| J. Physiol. 2006,572,295-305 |
ATP Cell Proliferation Assay
| Lars C Huber, Peter Kuenzler, Susan H Boyce, Beat A Michel, Renate E Gay, Barbara S Ink and Steffen Gay |
| Sirius - Effects of a novel tyrosine kinase inhibitor in rheumatoid arthritis synovial fibroblasts |
| Ann Rheum Dis.2008, 67: 389-394 |
| F. Jacobsen, A. Baraniskin, J. Mertens, D. Mittler, A. Mohammadi-Tabrisi, S. Schubert, M. Soltau, M. Lehnhardt, B. Behnke, S. Gatermann, H. U. Steinau and L. Steinstraesser |
| Orion - Activity of histone H1.2 in infected burn wounds |
| Journal of Antimicrobial Chemotherapy Volume 55, Number 5 Pp. 735-741 |
ATP Cell Viability Assay
| Mayte Coiras, Maria Rosa Lopez-Huertas, Elena Mateos, and Jose Alcami |
| Orion - Caspase-3-mediated cleavage of p65/RelA results in a carboxy-terminal fragment that inhibits I?B? and enhances HIV-1 replication in human T lymphocytes |
| Retrovirology. 2008, 5: 109. |
| Ji-Young Jang, Yun Choi, Yoon-Kyung Jeon and Chul-Woo Kim |
| Orion - Suppression of adenine nucleotide translocase-2 by vector-based siRNA in human breast cancer cells induces apoptosis and inhibits tumor growth in vitro and in vivo |
| Breast Cancer Research 2008, 10:R11 |
| Lynn S. Adams, Navindra P. Seeram, Mary L. Hardy, Catherine Carpenter and David Heber |
| Orion - Analysis of the Interactions of Botanical Extract Combinations Against the Viability of Prostate Cancer Cell Lines |
| eCAM 2006,3(1)117-124 |
| Jiang Li, Maria L. Spletter, Delinda A. Johnson, Lynda S. Wright , Clive N. Svendsen and Jeffrey A. Johnson |
| Orion - Rotenone-induced caspase 9/3-independent and -dependent cell death in undifferentiated and differentiated human neural stem cells |
| Journal of Neurochemistry Volume 92 Issue 3, Pages 462 - 476 |
ATP Proliferation Assay
| Bogusz Trojanowicz, Anja Winkler, Kathrin Hammje, Zhouxun Chen, Carsten Sekulla, Dagobert Glanz, Cornelia Schmutzler, Birgit Mentrup, Sabine Hombach-Klonisch, Thomas Klonisch, Rainer Finke, Josef Koehrle, Henning Dralle and Cuong Hoang-Vu |
| Sirius - Retinoic acid-mediated down-regulation of ENO1/MBP-1 gene products caused decreased invasiveness of the follicular thyroid carcinoma cell lines |
| Journal of Molecular Endocrinology (2009) 42 249-260 |
ATPase activity assay
| Jayati Mookerjee-Basu, Pierre Vantourout, Laurent O. Martinez, Bertrand Perret, Xavier Collet, Christian Perigaud, Suzanne Peyrottes, and Eric Champagne |
| Orion - F1-Adenosine Triphosphatase Displays Properties Characteristic of an Antigen Presentation Molecule for Vgamma9Vdelta2 T Cells |
| The Journal of Immunology, 2010, 184, 6920 -6928 |
Bacteria Detection (ATP)
| C. Sobral, L. Ferreira, J. Morgan, X. Cao, M. Ipolito, A. Filho |
| Sirius - Pseudomonas aeruginosa proliferation is diminished by KGF in experimental burn model using genetically modified keratinocytes |
| Burns, Volume 33, Issue 1, Pages S121-S121 |
| C. Sobral, A. Gragnani, J. Morgan, L. Ferreira |
| Sirius - Inhibition of proliferation of Pseudomonas aeruginosa by KGF in an experimental burn model using human cultured keratinocytes |
| Burns, Volume 33, Issue 5, Pages 613-620 |
Beta Galaktosidase Assay
| Lars Steinstraesser, Andrea Rittig, Kai Gevers, Michael Sorkin, Tobias Hirsch, Marco Kesting, Michael Sand, Sammy Al-Benna, Stefan Langer, Hans-Ulrich Steinau, and Frank Jacobsen |
| Orion - A Human Full-Skin Culture System for Interventional Studies |
| Eplasty. 2009, 9: e5. |
| Shirui Mao, Michael Neu, Oliver Germershaus, Olivia Merkel, Johannes Sitterberg, Udo Bakowsky and Thomas Kissel |
| Sirius - Influence of Polyethylene Glycol Chain Length on the Physicochemical and Biological Properties of Poly(ethylene imine)-graft-Poly(ethylene glycol) Block Copolymer/SiRNA Polyplexes |
| Bioconjugate Chem. 2006, 17, 1209-1218 |
Bioluminescence
| Claes JM, Mallefet J. |
| FB12 - Functional physiology of lantern shark (Etmopterus spinax) luminescent pattern: differential hormonal regulation of luminous zones. |
| J Exp Biol. 2010 Jun,213(Pt 11):1852-8. |
| Jenny Kronstrom, Samuel Dupont, Jerome Mallefet, Michael Thorndyke and Susanne Holmgren |
| FB12 - Serotonin and nitric oxide interaction in the control of bioluminescence in northern krill, Meganyctiphanes norvegica (M. Sars) |
| Journal of Experimental Biology 210, 3179-3187 (2007) |
Ca++/Aequorin
| Mehdi Zeinoddini, Khosro Khajeh, Farida Behzadian, Saman Hosseinkhani, Ali-Reza Saeedinia, Hesam Barjesteh |
| Sirius - Design and Characterization of an Aequorin-based Bacterial Biosensor for Detection of Toluene and Related Compounds |
| Photochem Photobiol. 2010 Jul 20 |
| V.L. Sukhorukov, J.M. Endter, D. Zimmermann, R. Shirakashi, S. Fehrmann, M. Kiesel, R. Reuss, D. Becker, R. Hedrich, E. Bamberg, Th. Roitsch, and U. Zimmermann |
| Sirius - Mechanisms of Electrically Mediated Cytosolic Ca2+ Transients in Aequorin- Transformed Tobacco Cells |
| Biophys. J. BioFAST: First Published August 3, 2007 |
| Stephen H. Loukin, Ching Kung, and Yoshiro Saimi |
| Sirius - Lipid perturbations sensitize osmotic down-shock activated Ca2+ influx, a yeast deletome analysis |
| The FASEB Journal. 2007, 21:1813-1820 |
| Nelly Pitteloud, Chengkang Zhang, Duarte Pignatelli, Jia-Da Li, Taneli Raivio, Lindsay W. Cole, Lacey Plummer, Elka E. Jacobson-Dickman, Pamela L. Mellon, Qun-Yong Zhou, and William F. Crowley, Jr |
| Sirius - Loss-of-function mutation in the prokineticin 2 gene causes Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism |
| PNAS, October 30, 2007, vol. 104,no. 44,17447-17452 |
| B. Bouizgarne, H. El-Maarouf-Bouteau, C. Frankart, D. Reboutier, K. Madiona, A. M. Pennarun, M. Monestiez, J. Trouverie, Z. Amiar, J. Briand, M. Brault, J. P. Rona, Y. Ouhdouch, I. El Hadrami, F. Bouteau |
| FB12 - Early physiological responses of Arabidopsis thaliana cells to fusaric acid: toxic and signalling effects |
| New Phytologist 169 (1) , 209-218 (2006) |
| LIONEL GARNIER, FRANCOISE SIMON-PLAS, PATRICE THULEAU, JEAN-PIERRE AGNEL, JEAN-PIERRE BLEIN, RAOUL RANJEVA, JEAN-LUC MONTILLET |
| Sirius - Cadmium affects tobacco cells by a series of three waves of reactive oxygen species that contribute to cytotoxicity |
| Plant, Cell & Environment Volume 29 Issue 10, Pages 1956 - 1969 |
| Tou Cheu Xiong, Alain Jauneau, Raoul Ranjeva and Christian Mazars |
| Sirius - Isolated plant nuclei as mechanical and thermal sensors involved in calcium signalling |
| The Plant Journal (2004) 40, 12-21 |
CALUX Assay (Dioxins, Estrogenic Compounds, etc.)
| Edwige Van der Heiden, Catherine Brasseur, Francois Brose, Danielle Melens, Emmanuel Dimartino, Marc Muller, Guy Maghuin-Rogister and Marie-Louise Scippo |
| Orion - CELL BASED ASSAY DIOXIN SCREENING: UTILISATION OF THREE NEW CELLULAR BIOASSAYS FROM DIFFERENT SPECIES AND TISSUES. |
| Organohalogen Compounds, Volume 70 (2008) page 002355 |
| David J. Brown, Jean Orelien, John D. Gordon, Andrew C. Chu, Michael D. Chu, Masafumi Nakamura, Hiroshi Handa, Fujio Kayama, Michael S. Denison, and George C. Clark |
| Orion - Mathematical Model Developed for Environmental Samples: Prediction of GC/MS Dioxin TEQ from XDS-CALUX Bioassay Data |
| Environ Sci Technol. 2007 June 15, 41(12): 4354?4360. |
| Jean-Francois Focanta, Gauthier Eppe, Marie-Louise Scippo, Anne-Cecile Massart, Catherine Pirard, Guy Maghuin-Rogister and Edwin De Pauw |
| Orion - Comprehensive two-dimensional gas chromatography with isotope dilution time-of-flight mass spectrometry for the measurement of dioxins and polychlorinated biphenyls in foodstuffs: Comparison with other methods |
| Journal of Chromatography A Volume 1086, Issues 1-2, 9 September 2005, Pages 45-60 |
Caspase Assay
| Silke Meister, Ulrich Schubert, Kirsten Neubert, Kai Herrmann, Renate Burger, Martin Gramatzki, Sabine Hahn, Sandra Schreiber, Sabine Wilhelm, Martin Herrmann, Hans-Martin Jaeck, and Reinhard E. Voll |
| Sirius - Extensive Immunoglobulin Production Sensitizes Myeloma Cells for Proteasome Inhibition |
| Cancer Res 2007, 67: (4). February 15, 2007 |
| D.S.Kim, J.A.Franklyn, V.E.Smith, A.L.Stratford, H.N.Pemberton, A.Warfield, J.C.Watkinson, T.Ishmail, M.J.O.Wakelam and C.J.McCabe |
| Orion - Securin induces genetic instability in colorectal cancer by inhibiting double-stranded DNA repair activity |
| Carcinogenesis vol.28 no.3 pp.749?759, 2007 |
| Yongmei Feng, Maria E. Ariza, Anne-Christine Goulet, Jiaqi Shi, Mark A. Nelson |
| Sirius - Death Signal Induced Relocalization of Cyclin Dependent Kinase 11 to Mitochondria |
| Biochem J. 2005 Nov 15, 392(Pt 1):65-73. |
| Feng, Y., Ariza, M.E., Goulet, A.C., Shi, J. and Nelson, M.A. |
| Sirius - Death signal induced relocalization of cyclin dependent kinase 11 to mitochondria |
| Biochem. J. 392(Pt.1) , 65-73 |
| Dae Kim, Helen Pemberton, Anna L Stratford, Kristien Buelaert, John C Watkinson, Victor Lopes, Jayne A Franklyn and Chris J McCabe |
| Orion - Pituitary tumour transforming gene (PTTG) induces genetic instability in thyroid cells |
| Oncogene (2005) 24, 4861?4866 |
Dual Luciferase Assay
| Kui Lin-Wang, Karen Bolitho, Karryn Grafton, Anne Kortstee, Sakuntala Karunairetnam, Tony K McGhie, Richard V Espley, Roger P Hellens, Andrew C Allan |
| Orion - An R2R3 MYB transcription factor associated with regulation of the anthocyanin biosynthetic pathway in Rosaceae |
| J Physiol 579.3 (2007) pp 657-670 |
| Shinya Ohashi, Mitsuteru Natsuizaka, Gabrielle S. Wong, Carmen Z. Michaylira, Katharine D. Grugan, Douglas B. Stairs, Jiri Kalabis, Maria E. Vega, Ross A. Kalman, Momo Nakagawa, Andres J. Klein-Szanto, Meenhard Herlyn, J. Alan Diehl, Anil K. Rustgi, and Hiroshi Nakagawa |
| Orion - Epidermal Growth Factor Receptor and Mutant p53 Expand an Esophageal Cellular Subpopulation Capable of Epithelial-to-Mesenchymal Transition through ZEB Transcription Factors |
| Cancer Res May 15, 2010 70, 4174 |
| Chen J, Yu H, Song W, Sun K, Song Y, Lou K, Yang T, Zhang Y, Hui R. |
| Sirius - Angiopoietin-2 promoter haplotypes confer an increased risk of stroke in a Chinese Han population |
| Clinical Science (2009) 117, (387-395) |
| Jose L. Vega, Carlos Puebla, Rodrigo Vasquez, Marcelo Farias, Julio Alarcon, Marcal Pastor-Anglada, Bernardo Krause, Paola Casanello and Luis Sobrevia |
| Sirius - TGF-beta-1 inhibits expression and activity of hENT1 in a nitric oxide-dependent manner in human umbilical vein endothelium |
| 1. Cardiovasc Res (2009) 82 (3): 458-467. |
| Salman M Hyder, Yayun Liang, Jianbo Wu and Vanessa Welbern |
| Sirius - Regulation of thrombospondin-1 by natural and synthetic progestins in human breast cancer cells |
| Endocrine-Related Cancer 16 (3) 809 -817 |
| Blesa JR, Prieto-Ruiz JA, Abraham BA, Harrison BL, Hegde AA, Hernandez-Yago J. |
| Orion - NRF-1 is the major transcription factor regulating the expression of the human TOMM34 gene |
| Biochemistry and Cell Biology |
| Laura Davies, Nirupama Karthikeyan, James T. Lynch, Elin-Alia Sial, Areti Gkourtsa, Constantinos Demonacos and Marija Krstic-Demonacos |
| Orion - Cross Talk of Signaling Pathways in the Regulation of the Glucocorticoid Receptor Function |
| Molecular Endocrinology 22 (6): 1331-1344 |
| Vijaya Chaturvedi, Leonid AÿSitailo, Jian-ZhongÿQin, BarbaraÿBodner, Mitchell FÿDenning, JonathanÿCurry, WengengÿZhang, DouglasÿBrash and Brian JÿNickoloff |
| Sirius - Knockdown of p53 levels in human keratinocytes accelerates Mcl-1 and Bcl-xL reduction thereby enhancing UV-light induced apoptosis |
| Oncogene (2005) 24, 5299?5312. |
Expression on Oocyte Membrane
| Ivan KADURIN, Andjelko GOLUBOVIC, Lilia LEISLE, Hermann SCHINDELIN and Stefan GRUENDER |
| Orion - Differential effects of N-glycans on surface expression suggest structural differences between the acid-sensing ion channel (ASIC) 1a and ASIC1b |
| Biochem. J. (2008) 412, 469-475 |
Fe-bioreporter Assay
| Christel S. Hassler, Michael R. Twiss, Dana F. Simon, and Kevin J. Wilkinson |
| FB14 - Porous underwater chamber (PUC) for in-situ determination of nutrient and pollutant bioavailability to microorganisms |
| Limnol. Oceanogr.: Methods 6, 2008, 277?287 |
| R. M. L. Mckay, David Port, George S. Bullerjahn, Mamoon M. D. Al-Rshaidat, Jeffrey A. Klimowicz, Robert W. Sterner, Tanya M. Smutka, Erik T. Brown and Robert M. Sherrell |
| FB14 - Bioavailable iron in oligotrophic Lake Superior assessed using biological reporters |
| Journal of Plankton Research 2005 27(10):1033-1044 |
Gaussia Luciferase Assay
| Inge Lindner, Nasr Y.A. Hemdan, Martin Buchold, Klaus Huse, Marina Bigl, Ilka Oerlecke, Albert Ricken, Frank Gaunitz, Ulrich Sack, Andreas Naumann, Margrit Hollborn, Dietmar Thal, Rolf Gebhardt and Gerd Birkenmeier |
| Orion - Alpha2-Macroglobulin Inhibits the Malignant Properties of Astrocytoma Cells by Impeding ?-Catenin Signaling |
| Cancer Research 70, 277, January 1, 2010. Published Online First January 1, 2010. |
| Kyeong-Ae Kim, Maral Yolamanova, Onofrio Zirafi, Nadia R Roan, Ludger Staendker, Wolf-Georg Forssmann, Adam Burgener, Nathalie Dejucq-Rainsford, Beatrice H Hahn, George M Shaw, Warner C Greene, Frank Kirchhoff, and Jan Muench |
| Orion - Semen-mediated enhancement of HIV infection is donor-dependent and correlates with the levels of SEVI |
| Retrovirology. 2010, 7: 55. |
Immunoassay
| FRIEDEMANN LAUBE |
| FB12 - Mannose-6-Phosphate/Insulin-like Growth Factor-II Receptor in Human Melanoma Cells: Effect of Ligands and Antibodies on the Receptor Expression |
| ANTICANCER RESEARCH 29: 1383-1388 (2009) |
| Julia Dambacher, Florian Beigel, Kathrin Zitzmann, Enrico de Toni, Burkhard Goeke, Helmut M. Diepolder, Christoph J. Auernhammer and Stephan Brand |
| Orion - The role of the novel Th17 cytokine IL-26 in intestinal inflammation |
| Gut. Published Online First: 15 May 2008 |
Kinase Assay
| Konark Mukherjee, Manu Sharma, Reinhard Jahn, Markus C. Wahl, and Thomas C. Suedhof |
| Orion - Evolution of CASK into a Mg2+-Sensitive Kinase |
| Sci. Signal., 27 April 2010 |
Luciferase Reporter Assay
| Kyle J. Nakamura, Johannes S. Gach, Laura Jones, Katherine Semrau, Jan Walter, Frederic Bibollet-Ruche, Julie M. Decker, Laura Heath, William D. Decker, Moses Sinkala, Chipepo Kankasa, Donald Thea, James Mullins, Louise Kuhn, Michael B. Zwick, and Grace M. Aldrovandi |
| Orion - 4E10-Resistant HIV-1 Isolated from Four Subjects with Rare Membrane-Proximal External Region Polymorphisms |
| PLoS One. 2010, 5(3): e9786. |
| Xiaojuan Chen, Courtney S. Larson, Jason West, Xiaomin Zhang, and Dixon B. Kaufman |
| Sirius - In Vivo Detection of Extrapancreatic Insulin Gene Expression in Diabetic Mice by Bioluminescence Imaging |
| PLoS One. 2010, 5(2): e9397. |
| Catherine C. Ho and Daniel J. Bernard |
| Orion - Bone Morphogenetic Protein 2 Acts via Inhibitor of DNA Binding Proteins to Synergistically Regulate Follicle-Stimulating Hormone beta Transcription with Activin A |
| Endocrinology Vol. 151, No. 7 3445-3453 |
| Maria Ines Barria, Angel Gonzalez, Jorge Vera-Otarola, Ursula Leon, Valeska Vollrath, Delphine Marsac, Octavio Monasterio, Tomas Perez-Acle, Alejandro Soza and Marcelo Lopez-Lastra |
| Sirius - Analysis of natural variants of the hepatitis C virus internal ribosome entry site reveals that primary sequence plays a key role in cap-independent translation |
| Nucleic Acids Research, 2009, Vol. 37, No. 3 957-971 |
| Bert Maier, Sabrina Wendt, Jens T. Vanselow, Thomas Wallach, Silke Reischl, Stefanie Oehmke, Andreas Schlosser, and Achim Kramer |
| Orion - A large-scale functional RNAi screen reveals a role for CK2 in the mammalian circadian clock |
| Genes Dev. March 15, 2009 23: 708-718 |
| S. R. James, J. A. Franklyn, B. J. Reaves, V. E. Smith, S. Y. Chan, T. G. Barrett, M. D. Kilby and C. J. McCabe |
| Orion - Monocarboxylate Transporter 8 in Neuronal Cell Growth |
| Endocrinology Vol. 150, No. 4 1961-1969 |
| UteÿRaffetseder, ThomasÿRauen, SonjaÿDjudjaj, MatthiasÿKretzler, AbdelazizÿEn-Nia, FrankÿTacke, Henning WÿZimmermann, Peter JÿNelson, Bjoern CÿFrye, JuergenÿFloege, IoannisÿStefanidis, ChristianÿWeber and Peter RÿMertens |
| Sirius - Differential regulation of chemokine CCL5 expression in monocytes/macrophages and renal cells by Y-box protein-1 |
| Kidney International (2009) 75, 185?196 |
| Kleemann E, Jekel N, Dailey LA, Roesler S, Fink L, Weissmann N, Schermuly R, Gessler T, Schmehl T, Roberts CJ, Seeger W, Kissel T. |
| Sirius - Enhanced gene expression and reduced toxicity in mice using polyplexes of low-molecular-weight poly(ethylene imine) for pulmonary gene delivery |
| J Drug Target. 2009 Sep, 17(8):638-51 |
| Katharina B Rothwangl and Lijun Rong |
| FB12 - Analysis of a conserved RGE/RGD motif in HCV E2 in mediating entry |
| Virology Journal 2009, 6:12 |
| Paula D. Bos, Xiang H.-F. Zhang, Cristina Nadal, Weiping Shu, Roger R. Gomis, Don X. Nguyen, Andy J. Minn, Marc J. van de Vijver, William L. Gerald, John A. Foekens and Joan Massague |
| Orion - Genes that mediate breast cancer metastasis to the brain |
| Nature 459, 1005-1009 (18 June 2009) |
| Beata Bak, Laura Carpio, Jinjing L Kipp, Pankaj Lamba, Ying Wang, Ren-Shan Ge, Matthew P Hardy, Kelly E Mayo and Daniel J Bernard |
| Orion - Activins regulate 17?-hydroxysteroid dehydrogenase type I transcription in murine gonadotrope cells |
| Journal of Endocrinology (2009) 201, 89-104 |
| Annette Kugler, Barbara Koehler, Klaus Palme, Patricia Wolff, and Petra Dietrich |
| Orion - Salt-dependent regulation of a CNG channel subfamily in Arabidopsis |
| BMC Plant Biol. 2009, 9: 140. |
| Young-Sam Keum, Peter Pil-Jae Chang, Ki Han Kwon, Xiaoling Yuan, Wenge Li, Longqin Hu and Ah-Ng Tony Kong |
| Sirius - 3-Morpholinopropyl isothiocyanate is a novel synthetic isothiocyanate that strongly induces the antioxidant response element-dependent Nrf2-mediated detoxifying/antioxidant enzymes in vitro and in vivo |
| Carcinogenesis 2008 29(3):594-599 |
| Natalya Belousova, Galina Mikheeva, Juri Gelovani, and Victor Krasnykh |
| Sirius - Modification of Adenovirus Capsid with a Designed Protein Ligand Yields a Gene Vector Targeted to a Major Molecular Marker of Cancer |
| J Virol. 2008 January, 82(2): 630-637. |
| Marta Vilalta, Irene R. Degano, Juli Bago, David Gould, Monica Santos, Mariano Garcia-Arranz, Ramon Ayats, Carme Fuster, Yuti Chernajovsky, Damian Garcia-Olmo, Nuria Rubio, Jeronimo Blanco. |
| Sirius - Biodistribution, Long-term Survival, and Safety of Human Adipose Tissue-derived Mesenchymal Stem Cells Transplanted in Nude Mice by High Sensitivity Non-invasive Bioluminescence Imaging |
| Stem Cells and Development. ahead of print |
| TESSY IYPE, DAVID G. TAYLOR, SUZANNE M. ZIESMANN, JAMES C. GARMEY, HIROTAKA WATADA, AND RAGHAVENDRA G. MIRMIRA |
| FB15 - The Transcriptional Repressor Nkx6.1 Also Functions as a Deoxyribonucleic Acid Context- Dependent Transcriptional Activator during Pancreatic Cell Differentiation: Evidence for Feedback Activation of the nkx6.1 Gene by Nkx6.1 |
| Molecular Endocrinology 18(6):1363-1375 |
| Gilson S. Baia, Stefano Stifani, Edna T. Kimura, Michael W. McDermott, Russell O. Pieper and Anita Lal |
| Sirius - Notch Activation Is Associated with Tetraploidy and Enhanced Chromosomal Instability in Meningiomas1 |
| Neoplasia, Volume 10 Number 6 June 2008 pp. 604-612 |
| Cameron N. Johnstone,1,2 Perry S. Mongroo,1,2,5 A. Sophie Rich,1 Michael Schupp,4 Mark J. Bowser,1,2 Andrew S. deLemos,1,2 John W. Tobias,7 Yingqiu Liu,8 Gregory E. Hannigan,5,6 and Anil K. Rustgi |
| Orion - Parvin-beta Inhibits Breast Cancer Tumorigenicity and Promotes CDK9-Mediated Peroxisome Proliferator-Activated Receptor Gamma 1 Phosphorylation |
| Mol Cell Biol. 2008 January, 28(2): 687?704. |
| Shixin Ye12, Caroline Koehrer1, Thomas Huber, Manija Kazmi, Pallavi Sachdev3, Elsa C.Y. Yan4, Aditi Bhagat4, Uttam L. RajBhandary5, and Thomas P. Sakmar |
| Sirius - Site-specific Incorporation of Keto Amino Acids into Functional G Protein-coupled Receptors Using Unnatural Amino Acid Mutagenesis |
| J. Biol. Chem., Vol. 283, Issue 3, 1525-1533, January 18, 2008 |
| Yongbo Liu, Dongsong Nie, Yuelong Huang and Guangxiu Lu |
| Sirius - RNAi-mediated knock-down of gene mN6A1 reduces cell proliferation and decreases protein translation |
| Mol Biol Rep. 2008 Apr 4 |
| Suganya Selvarajah, Bridget A. Puffer, Fang-Hua Lee, Ping Zhu, Yuxing Li, Richard Wyatt, Kenneth H. Roux, Robert W. Doms, Dennis R. Burton |
| Orion - Focused Dampening of Antibody Response to the Immunodominant Variable Loops by Engineered Soluble gp140 |
| AIDS Research and Human Retroviruses. February 1, 2008, 24(2): 301-314 |
| Imara Y. Perera,1, Chiu-Yueh Hung, Candace D. Moorea, Jill Stevenson-Paulik and Wendy F. Boss |
| Sirius - Transgenic Arabidopsis Plants Expressing the Type 1 Inositol 5-Phosphatase Exhibit Increased Drought Tolerance and Altered Abscisic Acid Signaling |
| The Plant Cell 20:2876-2893 (2008) |
| Mayte Coiras, Maria Rosa Lopez-Huertas, Elena Mateos, and Jose Alcami |
| Sirius - Caspase-3-mediated cleavage of p65/RelA results in a carboxy-terminal fragment that inhibits I?B? and enhances HIV-1 replication in human T lymphocytes |
| Retrovirology. 2008, 5: 109. |
| Kartika Padhan, Rinki Minakshi, Mohammad Aatif Bin Towheed and Shahid Jameel |
| Sirius - Severe acute respiratory syndrome coronavirus 3a protein activates the mitochondrial death pathway through p38 MAP kinase activation |
| J Gen Virol 89 (2008), 1960-1969 |
| Anjali J. de Souza, Jean S. Oak, Ryan Jordanhazy, Rosemarie H. DeKruyff, David A. Fruman, and Lawrence P. Kane |
| Orion - T Cell Ig and Mucin Domain-1-Mediated T Cell Activation Requires Recruitment and Activation of Phosphoinositide 3-Kinase |
| The Journal of Immunology, 2008, 180, 6518 -6526 |
| SIMON J. CRABB, ANGELA HAGUE, PETER W.M. JOHNSON and GRAHAM PACKHAM |
| Sirius - BAG-1 inhibits PPAR?-induced cell death, but not PPAR?-induced transcription, cell cycle arrest or differentiation in breast cancer cells |
| ONCOLOGY REPORTS 19: 689-696, 2008 |
| Anja Glanz, Jens-Christian Albrecht, Stefanie Heinemann, Bernhard Fleckenstein, Noah Isakov and Brigitte Biesinger |
| Orion - NF-kB activation by the viral oncoprotein StpC enhances IFN-gamma production in T cells |
| Immunology and Cell Biology (2008) 86, 622?630 |
| Gabriel Rinaldi, Maria E. Morales, Martin Cancela, Estela Castillo, Paul J. Brindley, Jose F. Tort |
| Sirius - Development of Functional Genomic Tools in Trematodes: RNA Interference and Luciferase Reporter Gene Activity in Fasciola hepatica |
| PLoS Negl Trop Dis. 2008 July, 2(7): e260 |
| Josh D. Nelson, Heather Kinkead, Florence M. Brunel, Dan Leaman, Richard Jensen, John M. Louis, Toshiaki Maruyama, Carole A. Bewley, Katherine Bowdish, G. Marius Clore, Philip E. Dawson, Shana Frederickson, Rose G. Mage, Douglas D. Richman, Dennis R. Burton, and Michael B. Zwick |
| Orion - Antibody Elicited Against the gp41 N-Heptad Repeat (NHR) Coiled-Coil Can Neutralize HIV-1 with Modest Potency but Non-neutralizing Antibodies Also Bind to NHR Mimetics |
| Virology. 2008 July 20, 377(1): 170?183. |
| Yea Ping Lin, PhD, Carolyn H. Thibodeaux, Jeremy A. Pen, PhD, George D. Ferry, MD and James Versalovic, MD, PhD |
| Sirius - Probiotic Lactobacillus reuteri Suppress Proinflammatory Cytokines via c-Jun |
| Inflamm Bowel Dis. Volume 14, Number 8, August 2008 |
| Oliver Germershaus, Michael Neu, Martin Behe and Thomas Kissel |
| Sirius - HER2 Targeted Polyplexes: The Effect of Polyplex Composition and Conjugation Chemistry on in Vitro and in Vivo Characteristics |
| Bioconjugate Chem., 2008, 19 (1), pp 244?253 |
| Oliver Germershaus, Shirui Mao, Johannes Sitterberg, Udo Bakowsky, Thomas Kissel |
| Sirius - Gene delivery using chitosan, trimethyl chitosan or polyethylenglycol-graft-trimethyl chitosan block copolymers: Establishment of structure?activity relationships in vitro |
| Journal of Controlled Release 125 (2008) 145?154 |
| Juliane Nguyen, Xiulan Xie, Michael Neu, Rio Dumitrascu, Regina Reul, Johannes Sitterberg, Udo Bakowsky, Ralph Schermuly, Ludger Fink, Thomas Schmehl, Tobias Gessler, Werner Seeger, Thomas Kissel |
| Sirius - Effects of cell-penetrating peptides and pegylation on transfection efficiency of polyethylenimine in mouse lungs |
| J Gene Med 2008, 10: 1236?1246. |
| Kao, Yu-Hsun, Hsieh, Hsing-Pang, Chitlimalla, Santhosh Kumar, Pan, Wen-Yu, Kuo, Ching-Chuan, Tsai, Yuan-Chin, Lin, Wen-Hsing, Chuang, Shuang-En, Chang, Jang-Yang |
| Sirius - A novel peroxisome proliferator-activated receptor alpha/gamma agonist, BPR1H0101, inhibits topoisomerase II catalytic activity in human cancer cells |
| Anti-Cancer Drugs: February 2008 - Volume 19 - Issue 2 - pp 151-158 |
| Jayita Sen, Amy Jacobs, Haiqing Jiang, Lijun Rong and Michael Caffrey |
| FB12 - The disulfide loop of gp41 is critical to the furin recognition site of HIV gp160 |
| Protein Sci. 2007 16: 1236-1241 |
| Thierry Walzer, Mathieu Blery, Julie Chaix, Nicolas Fuseri, Lionel Chasson, Scott H. Robbins,Sebastien Jaeger, Pascale Andre, Laurent Gauthier, Laurent Daniel, Karine Chemin, Yannis Morel, Marc Dalod, Jean Imbert, Michel Pierres, Alessandro Moretta, Francois Romagne, and Eric Vivier |
| Sirius - Identification, activation, and selective in vivo ablation of mouse NK cells via NKp46 |
| 3384-3389 PNAS February 27, 2007 vol. 104 no. 9 |
| Alan P. Kumar, Michelle Ker Xing Chang, Larry Fliegel, Shazib Pervaiz, Marie-Veronique Clement |
| Sirius - Oxidative Repression of NHE1 Gene Expression Involves Iron-mediated Caspase Activity Oxidative Repression of NHE1 Gene Expression Involves Iron-mediated Caspase Activity |
| Cell Death Differ. 2007 Oct,14(10):1733-46. |
| Shizuyo Sutou, Miho Kunishi, Toshiyuki Kudo, Pimprapar Wongsrikeao, Makoto Miyagishi and Takeshige Otoi |
| Sirius - Knockdown of the bovine prion gene PRNP by RNA interference (RNAi) technology |
| BMC Biotechnology 2007, 7:44 |
| Shilajit D. Kundu, Chung Lee, Benjamin K. Billips, Geoffrey M. Habermacher, Qiang Zhang, Victoria Liu, Larry Y. Wong, David J. Klumpp, Praveen Thumbikat |
| Sirius - The toll-like receptor pathway: A novel mechanism of infection-induced carcinogenesis of prostate epithelial cells |
| The Prostate Volume 68 Issue 2, Pages 223 - 229 |
| Josh D. Nelson, Florence M. Brunel, Richard Jensen, Emma T. Crooks, Rosa M. F. Cardoso, Meng Wang, Ann Hessell, Ian A. Wilson, James M. Binley, Philip E. Dawson, Dennis R. Burton, and Michael B. Zwick |
| Orion - An Affinity-Enhanced Neutralizing Antibody against the Membrane-Proximal External Region of Human Immunodeficiency Virus Type 1 gp41 Recognizes an Epitope between Those of 2F5 and 4E10 |
| Journal of Virology, April 2007, p. 4033-4043, Vol. 81, No. 8 |
| P Leister, A Felten, AI Chasan and KH Scheidtmann |
| Orion - ZIP kinase plays a crucial role in androgen receptor-mediated transcription |
| Oncogene (2007), 1?9 |
| Yan Xie, Dennis W. Wolff, Ming-Fong Lin, and Yaping Tu |
| Sirius - Vasoactive Intestinal Peptide Transactivates the Androgen Receptor through a Protein Kinase A-Dependent Extracellular Signal-Regulated Kinase Pathway in Prostate Cancer LNCaP Cells |
| Mol Pharmacol 72:73-85, 2007 |
| Sarah Tonack, Karen Kind, Jeremy G. Thompson, Anna M. Wobus, Bernd Fischer and Anne Navarrete Santos |
| Sirius - Dioxin Affects Glucose Transport via the Arylhydrocarbon Receptor Signal Cascade in Pluripotent Embryonic Carcinoma Cells |
| Endocrinology Vol. 148, No. 12 5902-5912 |
| Krohn R, Raffetseder U, Bot I, Zernecke A, Shagdarsuren E, Liehn EA, van Santbrink PJ, Nelson PJ, Biessen EA, Mertens PR, Weber C. |
| Sirius - Y-box binding protein-1 controls CC chemokine ligand-5 (CCL5) expression in smooth muscle cells and contributes to neointima formation in atherosclerosis-prone mice. |
| Circulation. 2007 Oct 16, 116(16):1812-20 |
| Maria Villa-Morales, Javier Santos, Eduardo Perez-Gomez, Miguel Quintanilla and Jose Fernandez-Piqueras |
| Sirius - A Role for the Fas/FasL System in Modulating Genetic Susceptibility to T-Cell Lymphoblastic Lymphomas |
| Cancer Research 67, 5107, June 1, 2007. |
| Shilajit D. Kundu, Chung Lee, Benjamin K. Billips, Geoffrey M. Habermacher, Qiang Zhang, Victoria Liu, Larry Y. Wong, David J. Klumpp, Praveen Thumbikat |
| Sirius - The toll-like receptor pathway: A novel mechanism of infection-induced carcinogenesis of prostate epithelial cells |
| The Prostate Volume 68 Issue 2, Pages 223 - 229 |
| Hugues Dardente, Erin E. Fortier, Vincent Martineau, and Nicolas Cermakian |
| Orion - Cryptochromes impair phosphorylation of transcriptional activators in the clock: a general mechanism for circadian repression |
| Biochem J. 2007 March 15, 402(Pt 3): 525?536. |
| Maria Villa-Morales, Javier Santos, Eduardo Perez-Gomez, Miguel Quintanilla and Jose Fernandez-Piqueras |
| Sirius - A Role for the Fas/FasL System in Modulating Genetic Susceptibility to T-Cell Lymphoblastic Lymphomas |
| Cancer Research 67, 5107, June 1, 2007 |
| Janet Rollins, Ingrid Veras, Stephanie Cabarcas, Ian Willis, and Laura Schramm |
| Sirius - Human Maf1 negatively regulates RNA Polymerase III transcription via the TFIIB family members Brf1 and Brf2 |
| Int J Biol Sci. 2007, 3(5): 292?302. |
| Michael Neu, Oliver Germershaus, Shirui Mao, Karl-Heinz Voigt, Martin Behe, Thomas Kissel |
| Sirius - Crosslinked nanocarriers based upon poly(ethylene imine) for systemic plasmid delivery: In vitro characterization and in vivo studies in mice |
| Journal of Controlled Release 118 (2007) 370?380 |
| J. L. Barton, T. Berg, L. Didon and M. Nord |
| Orion - The pattern recognition receptor Nod1 activates CCAAT/enhancer binding protein ? signalling in lung epithelial cells |
| ERJ August 1, 2007 vol. 30 no. 2 214-222 |
| Dennis Hoffmann and Oliver Wildner |
| Orion - Restriction of adenoviral replication to the transcriptional intersection of two different promoters for colorectal and pancreatic cancer treatment |
| Mol Cancer Ther. 2006, 5:374-381 |
| Dennis Hoffmann and Oliver Wildner |
| Orion - Efficient generation of double heterologous promoter controlled oncolytic adenovirus vectors by a single homologous recombination step in Escherichia coli |
| BMC Biotechnology 2006, 6:36 |
| MERITXELL HUCH, DANIEL ABATE-DAGA, JOSEP MARIA ROIG, JUAN RAMON GONZALEZ, JOAN FABREGAT, BARBARA SOSNOWSKI, ADELA MAZO, and CRISTINA FILLAT |
| Orion - Targeting the CYP2B1 / Cyclophosphamide Suicide System to Fibroblast Growth Factor Receptors Results in a Potent Antitumoral Response in Pancreatic Cancer Models |
| HUMAN GENE THERAPY 17:1 -14 (December 2006) |
| Sabine Hombach-Klonisch, Paola Pocar, Johannes Kauffold and Thomas Klonisch |
| Sirius - Dioxin Exerts Anti-estrogenic Actions in a Novel Dioxin-Responsive Telomerase-Immortalized Epithelial Cell Line of the Porcine Oviduct (TERT-OPEC) |
| Toxicological Sciences 2006 90(2):519-528 |
| Alexander H. Licht, Oliver T. Pein, Lore Florin, Bettina Hartenstein, Hendrik Reuter, Bernd Arnold, Peter Lichter, Peter Angel, and Marina Schorpp-Kistner |
| Sirius - JunB is required for endothelial cell morphogenesis by regulating core-binding factor beta |
| J Cell Biol. 2006 December 18, 175(6): 981-991. |
| Nevenka Juretic, Paola Garcia-Huidobro, Juan Antonio Iturrieta, Enrique Jaimovich and Nora Riveros |
| FB12 - Depolarization-induced slow Ca2+ transients stimulate transcription of IL-6 gene in skeletal muscle cells |
| Am J Physiol Cell Physiol 290:1428-1436, 2006 |
| Richard WHALEN, Xiangdang LIU and Thomas D. BOYER |
| Sirius - Identification of a short form of ubiquitin-specific protease 3 that is a repressor of rat glutathione S-transferase gene expression |
| Biochem. J. (2006) 394, 519-526 |
| Sai Duriseti, Paul T Winnard, Jr., Yelena Mironchik, Farhad Vesuna, Ana Raman, and Venu Raman |
| Sirius - HOXA5 Regulates hMLH1 Expression in Breast Cancer Cells |
| Neoplasia. 2006 April, 8(4): 250?258. |
| Rongsong Li, Kevin P. Mouillesseaux, Dennis Montoya, Daniel Cruz, Navid Gharavi, Martin Dun, Lukasz Koroniak, Judith A. Berliner |
| Sirius - Identification of Prostaglandin E2 Receptor Subtype 2 As a Receptor Activated by OxPAPC |
| Circ. Res. 2006,98,642-650, |
| Masatada Watanabe, Mariko Noda and Shizuo Nakajin |
| Sirius - Effect of epidermal growth factor and prostaglandin on the expression of aromatase (CYP19) in human adrenocorticalcarcinoma cell line NCI-H295R cells |
| Journal of Endocrinology (2006) 188, 59?68 |
| Oliver Germershaus, Thomas Merdan, Udo Bakowsky, Martin Behe and Thomas Kissel |
| Sirius - Trastuzumab-Polyethylenimine-Polyethylene Glycol Conjugates for Targeting Her2-Expressing Tumors |
| Bioconjugate Chem. 2006, 17, 1190-1199 |
| Chadrick E. Denlinger, MD, Brian K. Rundall, DO, David R. Jones, MD |
| Orion - Inhibition of phosphatidylinositol 3-kinase/Akt and histone deacetylase activity induces apoptosis in non-small cell lung cancer in vitro and in vivo |
| J Thorac Cardiovasc Surg 2005, 130:1422-1429 |
| Franck Rencurel, Alasdair Stenhouse, Simon A. Hawley, Thomas Friedberg, D. Grahame Hardie , Calum Sutherland, and C. Roland Wolf |
| Orion - AMP-activated Protein Kinase Mediates Phenobarbital Induction of CYP2B Gene Expression in Hepatocytes and a Newly Derived Human Hepatoma Cell Line |
| THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 280, No. 6, Issue of February 11, pp. 4367-4373, 2005 |
| Franck Morceau, Michael Schnekenburger, Romain Blasius, Isabelle Buck, Mario Dicato, Marc Diederich |
| Orion - Tumor necrosis factor alpha inhibits aclacinomycin A-induced erythroid differentiation of K562 cells via GATA-1 |
| Cancer Letters , Volume 240 , Issue 2 , Pages 203 - 212 |
| Ming Jiang, Andrey A. Arzumanov, Michael J. Gait and Jo Milner |
| Orion - A bi-functional siRNA construct induces RNA interference and also primes PCR amplification for its own quantification |
| Nucleic Acids Res. 2005 Oct 7,33(18):e151 |
| John J. Turner, Gabriela D. Ivanova, Birgit Verbeure, Donna Williams, Andrey A. Arzumanov, Said Abes, Bernard Lebleu, and Michael J. Gait |
| Orion - Cell-penetrating peptide conjugates of peptide nucleic acids (PNA) as inhibitors of HIV-1 Tat-dependent trans-activation in cells |
| Nucleic Acids Res. 2005, 33(21): 6837-6849. |
| Minghui Wang, Akseli Hemminki, Gene P. Siegal, Mack N. Barnes, Igor Dmitriev, Victor Krasnykh, Bin Liu, David T. Curiel, Ronald D. Alvarez |
| Orion - Adenoviruses with an RGD-4C modification of the fiber knob elicit a neutralizing antibody response but continue to allow enhanced gene delivery |
| Gynecologic Oncology 96 (2005) 341-348 |
| JIANBO WU 1 ,YAYUN LIANG, ZAFAR NAWAZ and SALMAN M.HYDER |
| Sirius - Complex agonist-like properties of ICI 182,780 (Faslodex) in human breast cancer cells that predominantly express progesterone receptor-B: Implications for treatment resistance |
| INTERNATIONAL JOURNAL OF ONCOLOGY 27:1647-1659,2005 |
| Jianbo Wu, Sandra Brandt and Salman M. Hyder |
| Sirius - Ligand- and Cell-Specific Effects of Signal Transduction Pathway Inhibitors on Progestin-Induced Vascular Endothelial Growth Factor Levels in Human Breast Cancer Cells |
| Molecular Endocrinology 19 (2): 312-326 |
| Jasmina Profirovic, Matvey Gorovoy, Jiaxin Niu, Sasa Pavlovic, , and Tatyana Voyno-Yasenetskaya, |
| Sirius - A Novel Mechanism of G Protein-dependent Phosphorylation of Vasodilator-stimulated Phosphoprotein* |
| J. Biol. Chem. 280 (38): 32866-32876 |
| Scott C. Wesselkamper, Lisa M. Case, Lisa N. Henning, Michael T. Borchers, Jay W. Tichelaar, John M. Mason, Nadine Dragin, Mario Medvedovic, Maureen A. Sartor, Craig R. Tomlinson and George D. Leikauf |
| Sirius - Gene Expression Changes during the Development of Acute Lung Injury: Role of Transforming Growth Factor-beta |
| American Journal of Respiratory and Critical Care Medicine, Dec 1, 2005 |
| David G. Taylor, Daniella Babu, and Raghavendra G. Mirmira |
| FB15 - The C-Terminal Domain of the Cell Homeodomain Factor Nkx6.1 Enhances Sequence-Selective DNA Binding at the insulin Promoter |
| Biochemistry, 44 (33), 11269 -11278, 2005 |
| Jonathan C. Schisler, Per Bo Jensen, David G. Taylor, Thomas C. Becker, Filip Krag Knop, Shiro Takekawa, Michael German, Gordon C. Weir, Danhong Lu, Raghavendra G. Mirmira, and Christopher B. Newgard |
| FB15 - The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells |
| PNAS May 17, 2005 vol. 102 no. 20 7297-7302 |
| M. K. Koohi, R. Ivell and N. Walther |
| Sirius - Transcriptional Activation of the Oxytocin Promoter by Oestrogens Uses a Novel Non-Classical Mechanism of Oestrogen Receptor Action |
| Volume 17 Issue 4 Page 197-207, April 2005 |
| Siew Hui Lwa and Wei Ning Chen |
| Sirius - Hepatitis B virus X protein interacts with beta5 subunit of heterotrimeric guanine nucleotide binding protein |
| Virology Journal 2005, 2:76 |
| Scott C. Wesselkamper, Lisa M. Case, Lisa N. Henning, Michael T. Borchers, Jay W. Tichelaar, John M. Mason, Nadine Dragin, Mario Medvedovic, Maureen A. Sartor, Craig R. Tomlinson and George D. Leikauf |
| Sirius - Gene Expression Changes during the Development of Acute Lung Injury Role of Transforming Growth Factor |
| American Journal of Respiratory and Critical Care Medicine Vol 172. pp. 1399-1411, (2005) |
| JUDITH JIMENEZ, GWENDOLYN M. JANG, BERT L. SEMLER, and MARIAN L. WATERMAN |
| Sirius - An internal ribosome entry site mediates translation of lymphoid enhancer factor-1 |
| RNA. 2005 September, 11(9): 1385?1399. |
| Fang Shen, Matthew J. Ruddy, Pascale Plamondon and Sarah L. Gaffen |
| Orion - Cytokines link osteoblasts and inflammation: microarray analysis of interleukin-17- and TNF--induced genes in bone cells |
| Journal of Leukocyte Biology. 2005, 77:388-399 |
| Chadrick E. Denlinger, MD, Brian K. Rundall, DO, and David R. Jones, MD |
| Orion - Inhibition of phosphatidylinositol 3-kinase/Akt and histone deacetylase activity induces apoptosis in non?small cell lung cancer in vitro and in vivo |
| J Thorac Cardiovasc Surg 2005,130:1422-9 |
| Chandrashekhar Korgaonkar, Jussara Hagen, Van Tompkins, April A. Frazier, Chantal Allamargot, Frederick W. Quelle, and Dawn E. Quelle |
| Sirius - Nucleophosmin (B23) Targets ARF to Nucleoli and Inhibits Its Function |
| Molecular and Cellular Biology, February 2005, p. 1258-1271, Vol. 25, No. 4 |
| Susanne Kramer-Haemmerle, Francesca Ceccherini-Silberstein, Christian Bickel, Horst Wolff, Michelle Vincendeau, Thomas Werner, Volker Erfle, and Ruth Brack-Werner |
| Orion - Identification of a novel Rev-interacting cellular protein |
| BMC Cell Biol. 2005, 6: 20. |
| Valerie Mongrain, Xuan Ruan, Hugues Dardente, Erin E. Fortier and Nicolas Cermakian |
| Sirius - Hepatitis C Virus Core Protein Induces an Anergic State Characterized by Decreased Interleukin-2 Production and Perturbation of Mitogen-Activated Protein Kinase Responses |
| J Virol. 2005 February, 79(4): 2230?2239. |
| Jochen Dahm-Daphi, Petra Hubbe, Fruzsina Horvath, Raafat A El-Awady, Katie E Bouffard, Simon N Powell and Henning Willers |
| Sirius - Nonhomologous end-joining of site-specific but not of radiation-induced DNA double-strand breaks is reduced in the presence of wild-type p53 |
| Oncogene (2005) 24, 1663?1672. |
| Matthew J. Ruddy, Grace C. Wong , Xikui K. Liu, Hiroyasu Yamamoto, Soji Kasayama, Keith L. Kirkwood, and Sarah L. Gaffen |
| MPL2 - Functional Cooperation between Interleukin-17 and Tumor Necrosis Factor- Is Mediated by CCAAT/Enhancer-binding Protein Family Members |
| THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 279, No. 4, Issue of January 23, pp. 2559-2567, 2004 |
| Franck Morceau, Annelyse Duvoix, Sylvie Delhalle, Michael Schnekenburger, Mario Dicato, Marc Diederich |
| Orion - Regulation of glutathione S-transferase P1-1 gene expression by NF-kappaB in tumor necrosis factor alpha-treated K562 leukemia cells |
| Biochemical Pharmacology 67 (2004) 1227-1238 |
| Kristen A. Lantz, Marko Z. Vatamaniuk, John E. Brestelli, Joshua R. Friedman, Franz M. Matschinsky and Klaus H. Kaestner |
| Orion - Foxa2 regulates multiple pathways of insulin secretion |
| J. Clin. Invest. 114:512-520 (2004). |
| Elisabeth NASCHBERGER, Thomas WERNER, Ana B. VICENTE, Eric GUENZI, Kristin TOEPOLT, Rene LEUBERT, Clara LUBESEDER-MARTELLATO, Peter J. NELSON and Michael STueRZL |
| Orion - Nuclear factor-kB motif and interferon-a-stimulated response element co-operate in the activation of guanylate-binding protein-1 expression by inflammatory cytokines in endothelial cells |
| Biochem. J. (2004) 379 (409-420) |
| Juliane Platz, Christoph Beisswenger, Alexander Dalpke, Rembert Koczulla, Olaf Pinkenburg, Claus Vogelmeier, and Robert Bals |
| FB12 - Microbial DNA Induces a Host Defense Reaction of Human Respiratory Epithelial Cells |
| The Journal of Immunology, 2004, 173: 1219-1223. |
| Jianbo Wu, Jennifer Richer, Kathryn B. Horwitz, and Salman M. Hyder |
| Sirius - Progestin-Dependent Induction of Vascular Endothelial Growth Factor in Human Breast Cancer Cells: Preferential Regulation by Progesterone Receptor B |
| CANCER RESEARCH 64, 2238-2244, March 15, 2004 |
| MARC E. VAN EDEN, MARSHALL P. BYRD, KYLE W. SHERRILL, and RICHARD E. LLOYD |
| Sirius - Translation of cellular inhibitor of apoptosis protein 1 (c-IAP1) mRNA is IRES mediated and regulated during cell stress |
| RNA. 2004 March, 10(3): 469-481. |
| MARC E. VAN EDEN, MARSHALL P. BYRD, KYLE W. SHERRILL and RICHARD E. LLOYD |
| Sirius - mRNA is IRES mediated and regulated during cell stress Translation of cellular inhibitor of apoptosis protein 1 (c-IAP1) |
| RNA, Vol. 10, No. 3 2004: 469-481. |
| Sanjay Kumar, Gandham Mahendra, Tim R. Nagy, Dr. Selvarangan Ponnazhagan |
| Sirius - Osteogenic Differentiation of Recombinant Adeno-Associated Virus 2-Transduced Murine Mesenchymal Stem Cells and Development of an Immunocompetent Mouse Model for Ex Vivo Osteoporosis Gene Therapy |
| Human Gene Therapy Dec 2004, Vol. 15, No. 12 : 1197 -1206 |
| Massimo C. Fantini, Christoph Becker, Giovanni Monteleone, Francesco Pallone, Peter R. Galle, and Markus F. Neurath |
| Sirius - Cutting Edge: TGF-beta Induces a Regulatory Phenotype in CD4 CD25 T Cells through Foxp3 Induction and Down-Regulation of Smad7 |
| The Journal of Immunology, 2004, 172: 5149-5153. |
| Laura G. Barrientos, Fatima Lasala, Joaquin R. Otero, Anthony Sanchez, and Rafael Delgado |
| Sirius - In Vitro Evaluation of Cyanovirin-N Antiviral Activity, by Use of Lentiviral Vectors Pseudotyped with Filovirus Envelope Glycoproteins |
| The Journal of Infectious Diseases 2004,189:1440-1443 |
| Sabbi Lall, Cassandra C. Friedman, Marzena Jankowska-Anyszka, Janusz Stepinski, Edward Darzynkiewicz, and Richard E. Davis |
| Sirius - Contribution of trans-splicing, 5?-leader length, cap-poly(A) synergism, and initiation factors to nematode translation in an Ascaris suum embryo cell-free system |
| THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 279, No. 44, Issue of October 29, pp. 45573-45585, 2004 |
| Yong Zhou, James S. Hagood, and Joanne E. Murphy-Ullrich |
| Orion - Thy-1 Expression Regulates the Ability of Rat Lung Fibroblasts to Activate Transforming Growth Factor-? in Response to Fibrogenic Stimuli |
| Am J Pathol. 2004 August, 165(2): 659-669. |
| JESSICA K. WICKENHEISSER, VELEN L. NELSON-DEGRAVE, PATRICK G. QUINN, AND JAN M. MCALLISTER |
| Sirius - Increased Cytochrome P450 17-alpha-Hydroxylase Promoter Function in Theca Cells Isolated from Patients with Polycystic Ovary Syndrome Involves Nuclear Factor-1 |
| Molecular Endocrinology 18(3):588?605 |
| Guoxiang Shen, Vidya Hebbar, Sujit Nair, Changjiang Xu, Wenge Li, Wen Lin, Young-Sam Keum, Jiahuai Han, Michael A. Gallo, and A.-N. Tony Kong |
| Sirius - Regulation of Nrf2 Transactivation Domain Activity. THE DIFFERENTIAL EFFECTS OF MITOGEN-ACTIVATED PROTEIN KINASE CASCADES AND SYNERGISTIC STIMULATORY EFFECT OF Raf AND CREB-BINDING PROTEIN |
| THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 279, No. 22, Issue of May 28, pp. 23052?23060, 2004 |
| Lawrence S. Stennett, Adam I. Riker, Tara M. Kroll, Janine Chamberlin, Toru Miki, Brian J. Nickoloff and I. Caroline Le Poole |
| Sirius - Expression of gp100 and CDK2 in Melanoma Cells is not Co-Regulated by a Shared Promoter Region |
| Pigment Cell Research Volume 17 Issue 5, Pages 525 - 532 |
| Christoph Becker, Stefan Wirtz, Manfred Blessing, Jaana Pirhonen, Dennis Strand, Oliver Bechthold, Julia Frick, Peter R. Galle, Ingo Autenrieth, and Markus F. Neurath |
| Sirius - Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells |
| J. Clin. Invest. 112:693-706 (2003). |
| MA Arangoa, N Duezguenes and C Tros de Ilarduya |
| Sirius - Increased receptor-mediated gene delivery to the liver by protamine-enhanced-asialofetuin-lipoplexes |
| Gene Therapy (2003) 10, 5-14. |
| Corrado Corti, Richard W. E. Clarkson, Luca Crepaldi, Cinzia F. Sala, John H. Xuereb and Francesco Ferraguti |
| Sirius - Gene Structure of the Human Metabotropic Glutamate Receptor 5 and Functional Analysis of Ist Multiple Promoters in Neuroblastoma and Astroglioma Cells |
| J. Biol. Chem., Vol. 278, Issue 35, 33105-33119, August 29, 2003 |
| Nathalie Hill-Kapturczak, Eric Sikorski, Christy Voakes, Jairo Garcia,Harry S. Nick, and Anupam Agarwal |
| Sirius - An internal enhancer regulates heme- and cadmium-mediated induction of human heme oxygenase-1 |
| Am J Physiol Renal Physiol 285: F515-F523, 2003. |
| JASHMIN VYAS, ANDROULLA ELIA, and MICHAEL J. CLEMENS |
| Sirius - Inhibition of the protein kinase PKR by the internal ribosome entry site of hepatitis C virus genomic RNA |
| RNA. 2003 July, 9(7): 858-870. |
| Natalia Wright, Teresa Lain de Lera, Carelia Garcia-Moruja, Rosa Lillo, Felix Garcia-Sanchez, Antonio Caruz, and Joaquin Teixido |
| Sirius - Transforming growth factor- 1 down-regulates expression of chemokine stromal cell-derived factor-1: functional consequences in cell migration and adhesion |
| BLOOD, 15 SEPTEMBER 2003 VOLUME 102, NUMBER 6 |
| Armin Volz, Anke Ehlers, Ruth Younger, Simon Forbes, John Trowsdale, Dietmar Schnorr, Stephan Beck and Andreas Ziegler |
| Sirius - Complex Transcription and Splicing of Odorant Receptor Genes |
| J. Biol. Chem., Vol. 278, Issue 22, 19691-19701, May 30, 2003 |
| Xintao Shuai, Thomas Merdan, Florian Unger, Matthias Wittmar, and Thomas Kissel |
| Sirius - Novel Biodegradable Ternary Copolymers hy-PEI-g-PCL-b-PEG: Synthesis, Characterization, and Potential as Efficient Nonviral Gene Delivery Vectors |
| Macromolecules, 2003, 36 (15), pp 5751?5759 |
| Hans-Peter Zenner, and Marlies Knipper Thomas Weber, Ulrike Zimmermann, Harald Winter, Andreas Mack, Iris Koepschall, Karin Rohbock |
| Orion - Thyroid hormone is a critical determinant for the regulation of the cochlear motor protein prestin |
| 2002,99,2901-2906, originally published online Feb 26, 2002, PNAS |
| AKSELI HEMMINKI, MINGHUI WANG, RENEE A. DESMOND, THERESA V. STRONG, RONALD D. ALVAREZ, and DAVID T. CURIEL |
| Orion - Serum and Ascites Neutralizing Antibodies in Ovarian Cancer Patients Treated with Intraperitoneal Adenoviral Gene Therapy |
| HUMAN GENE THERAPY 13:1505-1514 (August 10, 2002) |
| Elisa Lorenzo, Carmen Ruiz-Ruiz, Antonio Jesus Quesada, Gabriela Hernandez, Antonio Rodriguez, Abelardo Lopez-Rivas, and Juan Miguel Redondo |
| Sirius - Doxorubicin Induces Apoptosis and CD95 Gene Expression in Human Primary Endothelial Cells through a p53-dependent Mechanism |
| J. Biol. Chem., Vol. 277, Issue 13, 10883-10892, March 29, 2002 |
| Jingqiu Li, Michael Rehli, Barbara Timblin, Fulong Tan, Stefan W. Krause and Randal A. Skidgel |
| Sirius - Structure of the human carboxypeptidase M gene. Identification of a proximal GC-rich promoter and a unique distal promoter that consists of repetitive elements |
| Gene Volume 284, Issues 1-2, 6 February 2002, Pages 189-202 |
| Dik Hagenbeek and Christopher D. Rock |
| FB15 - Quantitative Analysis by Flow Cytometry of Abscisic Acid-Inducible Gene Expression in Transiently Transformed Rice Protoplasts |
| Cytometry 45:170-179, 2001. |
| Raman P. NAGARAJAN, Feifei CHEN, Wie LI, Eva VIG, Maureen A. HARRINGTON, Harikrishna NAKSHATRI and Yan CHEN |
| FB12 - Repression of transforming-growth-factor-?-mediated transcription by nuclear factor kB |
| Biochem. J. (2000) 348, (591-596) |
| Andrea Felten, Peter Leister, Sven Burgdorf, Lutz Uhlmann and Karl Heinz Scheidtmann |
| Orion - Characterization of rat BLOS2/Ceap, a putative yeast She3 homolog, as interaction partner of apoptosis antagonizing transcription factor/Che-1 |
| Biol. Chem., Vol. 388, pp. 569?582, June 2007 |
Luciferase Research
| Bagher Said Alipour, Saman Hosseinkhani, Sussan K. Ardestani and Ali Moradi |
| Sirius - The effective role of positive charge saturation in bioluminescence color and thermostability of firefly luciferase |
| Photochem. Photobiol. Sci., 2009, 8, 847 - 855 |
| Ali Moradi, Saman Hosseinkhani, Hossein Naderi-Manesh, Majid Sadeghizadeh and Bagher Said Alipour |
| Sirius - Effect of Charge Distribution in a Flexible Loop on the Bioluminescence Color of Firefly Luciferases |
| Biochemistry, 2009, 48 (3), pp 575?582 |
| Narges Kh. TAFRESHI, Majid SADEGHIZADEH, Rahman EMAMZADEH, Bijan RANJBAR, Hossein NADERI-MANESH and Saman HOSSEINKHANI |
| Orion - Site-directed mutagenesis of firefly luciferase: implication of conserved residue(s) in bioluminescence emission spectra among firefly luciferases |
| Biochem. J. (2008) 412, 27-33 |
| Mojtaba Mortazavi, Saman Hosseinkhani, Khosro Khajeh, Bijan Ranjbar, and A. Rahman Emamzadeh |
| Sirius - Spectroscopic and functional characterization of Lampyris turkestanicus luciferase: a comparative study |
| Acta Biochim Biophys Sin 2008, 40: 365-374 |
Lucigenin-enhanced chemiluminescence / ROS
| Katrin Dietl, Kathrin Renner, Katja Dettmer, Birgit Timischl, Karin Eberhart, Christoph Dorn, Claus Hellerbrand, Michael Kastenberger, Leoni A. Kunz-Schughart, Peter J. Oefner, Reinhard Andreesen, Eva Gottfried and Marina P. Kreutz |
| Sirius - Lactic Acid and Acidification Inhibit TNF Secretion and Glycolysis of Human Monocytes |
| The Journal of Immunology, 2010, 184, 1200 -1209 |
| Jing Yang, Pascale H. Lane, Jennifer S. Pollock, Pamela K. Carmines |
| Sirius - Protein Kinase C-Dependent NAD(P)H Oxidase Activation Induced by Type 1 Diabetes in Renal Medullary Thick Ascending Limb |
| Hypertension. 2010, 55:468 |
| Ping Xin, Wei Zhu, Jing Li, Shixin Ma, Lixing Wang, Mingya Liu, Jingbo Li, Meng Wei, and Andrew N. Redington |
| Sirius - Combined local ischemic postconditioning and remote perconditioning recapitulate cardioprotective effects of local ischemic preconditioning |
| Am J Physiol Heart Circ Physiol 298: H1819-H1831, 2010 |
| Yi Chang, Cheng-Ying Hsieh, Zi-Aa Peng, Ting-Lin Yen, George Hsiao, Duen-Suey Chou, Chien-Ming Chen and Joen-Rong Sheu |
| Orion - Neuroprotective mechanisms of puerarin in middle cerebral artery occlusion-induced brain infarction in rats |
| Journal of Biomedical Science 2009, 16:9 |
| Manuela Voinea Calin, Ileana Manduteanu, Elena Dragomir, Emanuel Dragan, Manuela Nicolae, Ana Maria Gan and Maya Simionescu |
| FB12 - Effect of depletion of monocytes/macrophages on early aortic valve lesion in experimental hyperlipidemia |
| Cell and Tissue Research Volume 336, Number 2 / Mai 2009 |
| Kay L.H. Wu, Chin Hsu, Julie Y.H. Chan |
| Sirius - Nitric Oxide and Superoxide Anion Differentially Activate Poly(ADP-ribose) Polymerase-1 and Bax to Induce Nuclear Translocation of Apoptosis-Inducing Factor and Mitochondrial Release of Cytochrome c after Spinal Cord Injury |
| Journal of Neurotrauma. July 2009, 26(7): 965-977 |
| Samuel H.H. Chan, Kay L.H. Wu, Alice Y.W. Chang, Ming-Hon Tai, Julie Y.H. Chan |
| Sirius - Oxidative Impairment of Mitochondrial Electron Transport Chain Complexes in Rostral Ventrolateral Medulla Contributes to Neurogenic Hypertension |
| Hypertension 2009,53,217-227, |
| Denise M. McDonald, Gary Coleman, Ashay Bhatwadekar, Tom A. Gardiner, and Alan W. Stitt |
| Sirius - Advanced glycation of the Arg-Gly-Asp (RGD) tripeptide motif modulates retinal microvascular endothelial cell dysfunction |
| Mol Vis. 2009, 15: 1509?1520 |
| N. Hedayati, S. Annambhotla, J. Jiang, X. Wang, H. Chai, P. Lin, Q. Yao, C. Chen |
| Sirius - Growth hormone?releasing peptide ghrelin inhibits homocysteine-induced endothelial dysfunction in porcine coronary arteries and human endothelial cells |
| Journal of Vascular Surgery, Volume 49, Issue 1, Pages 199-207 |
| Yi Chang, Cheng-Ying Hsieh, Zi-Aa Peng, Ting-Lin Yen, George Hsiao, Duen-Suey Chou, Chien-Ming Chen and Joen-Rong Sheu |
| Orion - Neuroprotective mechanisms of puerarin in middle cerebral artery occlusion-induced brain infarction in rats |
| Journal of Biomedical Science 2009, 16:9 |
| Han-Jun Wang, Yan-Xia Pan, Wei-Zhong Wang, Irving H. Zucker, and Wei Wang |
| Sirius - NADPH oxidase-derived reactive oxygen species in skeletal muscle modulates the exercise pressor reflex |
| J Appl Physiol 107: 450-459, 2009. |
| Gina Sanchez, Matias Escobar, Zully Pedrozo, Pilar Macho, Raul Domenech, Steffen Haertel, Cecilia Hidalgo and Paulina Donoso |
| FB12 - Exercise and tachycardia increase NADPH oxidase and ryanodine receptor-2 activity: possible role in cardioprotection |
| Cardiovascular Research 2008 77(2):380-386 |
| M. Czesnikiewicz-Guzik, B. Lorkowska, J. Zapala, M. Czajka, M. Szuta, B. Loster, TJ. Guzik, R. Korbut |
| FB12 - NADPH OXIDASE AND UNCOUPLED NITRIC OXIDE SYNTHASE ARE MAJOR SOURCES OF REACTIVE OXYGEN SPECIES IN ORAL SQUAMOUS CELL CARCINOMA. POTENTIAL IMPLICATIONS FOR IMMUNE REGULATION UNDER HIGH OXIDATIVE STRESS CONDITIONS. |
| J Physiol Pharmacol. 2008 Mar,59(1):139-52. |
| Yuan He, Kar Wah Leung, Yue-Hong Zhang, Shan Duan, Xiu-Feng Zhong, Ru-Zhang Jiang, Zhan Peng, Joyce Tombran-Tink, and Jian Ge |
| Orion - Mitochondrial Complex I Defect Induces ROS Release and Degeneration in Trabecular Meshwork Cells of POAG Patients: Protection by Antioxidants |
| Investigative Ophthalmology and Visual Science. 2008, 49:1447-1458 |
| Kyoko Ueda, MS, Fumio Tsuji, PhD, Tomoko Hirata, MS, Masanori Takaoka, PhD, and Yasuo Matsumura, PhD |
| Sirius - Preventive Effect of TRPV1 Agonists Capsaicin and Resiniferatoxin on Ischemia/Reperfusion-induced Renal Injury in Rats |
| J Cardiovasc Pharmacol Volume 51, Number 5, May 2008 |
| ROGHAIR, ROBERT D. MILLER, FRANCIS J JR. SCHOLZ, THOMAS D. LAMB, FRED S. SEGAR, JEFFREY L. |
| FB12 - Coronary Constriction to Angiotensin II Is Enhanced by Endothelial Superoxide Production in Sheep Programmed by Dexamethasone. |
| Pediatric Research. 63(4):370-374, April 2008. |
| Young M. Kim, BSc, Hassan Kattach, MRCS, Chandi Ratnatunga, FRCS, Ravi Pillai, FRCS, Keith M. Channon, MD, FRCP and Barbara Casadei, MD, DPhil, FRCP |
| FB12 - Association of Atrial Nicotinamide Adenine Dinucleotide Phosphate Oxidase Activity With the Development of Atrial Fibrillation After Cardiac Surgery |
| J Am Coll Cardiol, 2008, 51:68-74 |
| Robert D. Roghaira, Francis J. Miller, Jr.b, Thomas D. Scholza, Fred S. Lamba, Jeffrey L. Segara |
| FB12 - Endothelial Superoxide Production Is Altered in Sheep Programmed by Early Gestation Dexamethasone Exposure |
| Neonatology 2008,93:19-27 |
| Guillermo B. Silva, Jeffrey L. Garvin |
| Sirius - Angiotensin II?Dependent Hypertension Increases Na Transport-Related Oxygen Consumption by the Thick Ascending Limb |
| Hypertension 2008,52,1091-1098 |
| Ling-Chang Kung, Samuel H. H. Chan, Kay L. H. Wu, Chen-Chun Ou, Ming-Hon Tai, and Julie Y. H. Chan |
| Sirius - Mitochondrial Respiratory Enzyme Complexes in Rostral Ventrolateral Medulla as Cellular Targets of Nitric Oxide and Superoxide Interaction in the Antagonism of Antihypertensive Action of eNOS Transgene |
| Mol Pharmacol 74:1319-1332, 2008 |
| Br J Pharmacol. 2008 July, 154(6): 1327?1338. |
| Orion - Anti-inflammatory effects of dimemorfan on inflammatory cells and LPS-induced endotoxin shock in mice |
| (Hypertension. 2008, 51:500.) |
| G . Oudit , Z . Kassiri , M . Patel , M . Chappell , J . Butany , P . Backx , R . Tsushima , J . Scholey , R . Khokha , J . Penninger |
| FB12 - Angiotensin II-mediated oxidative stress and inflammation mediate the age-dependent cardiomyopathy in ACE2 null mice |
| Cardiovascular Research 2007 75(1):29-39 |
| Kaczynski Z, Braun S, Lindner B, Niehaus K, Holst O. |
| Sirius - Investigation of the chemical structure and biological activity of oligosaccharides isolated from rough-type Xanthomonas campestris pv. campestris B100 lipopolysaccharide |
| J Endotoxin Res. 2007, 13(2):101-8. |
| Tellstroem V, Usadel B, Thimm O, Stitt M, Kuester H, Niehaus K. |
| Sirius - The lipopolysaccharide of Sinorhizobium meliloti suppresses defense-associated gene expression in cell cultures of the host plant Medicago truncatula. |
| Plant Physiol. 2007 Feb, 143(2):825-37 |
| Yan-Xia Pan, Lie Gao, Wei-Zhong Wang, Hong Zheng, Dongmei Liu, Kaushik P. Patel, Irving H. Zucker, Wei Wang |
| Sirius - Exercise Training Prevents Arterial in Rats Treated With Central Angiotensin IIBaroreflex Dysfunction |
| Hypertension 2007, 49, 519-527 |
| Masi, Laura MD, Recenti, Raffaella BSc, Silvestri, Sandra MD, Pinzani, Pamela BSc, Pepi, Monica, Paglierani, Milena BSc , Brandi, Maria Luisa MD, Franchi, Alessandro MD |
| Orion - Expression of Cyclooxygenase-2 in Osteosarcoma of Bone |
| Applied Immunohistochemistry & Molecular Morphology. 15(1):70-76, March 2007 |
| S. Y. Yeung, C. S. Huang, C. P. Chan, C. P. Lin, H. N. Lin, P. H. Lee, H. W. Jia, S. K. Huang, J. H. Jeng, M. C. Chang |
| Orion - Antioxidant and pro-oxidant properties of chlorhexidine and its interaction with calcium hydroxide solutions |
| International Endodontic Journal 40 (11), 837-844 (2007) |
| Bjoern Szotowski, Silvio Antoniak, Petra Goldin-Lang, Quoc-Viet Tran, Klaus Pels, Peter Rosenthal, Vladimir Y. Bogdanov, Hans-Hubert Borchert, Heinz-Peter Schultheiss and Ursula Rauch |
| Orion - Antioxidative treatment inhibits the release of thrombogenic tissue factor from irradiation- and cytokine-induced endothelial cells |
| Cardiovascular Research 2007 73(4):806-812 |
| Miller, Francis J. Jr, Filali, Mohammed, Huss, Gina J., Stanic, Bojana, Chamseddine, Ali, Barna, Thomas J., Lamb, Fred S. |
| FB12 - Cytokine activation of nuclear factor kappa B in vascular smooth muscle cells requires signaling endosomes containing Nox1 and ClC-3 |
| Circulation Research:Volume 101(7)28 September 2007pp 663-671 |
| Qin Fang, Hong Sun, Denise M. Arrick, and William G. Mayhan |
| Sirius - Inhibition of NADPH oxidase improves impaired reactivity of pial arterioles during chronic exposure to nicotine |
| J Appl Physiol 100: 631-636, 2006 |
| Daisuke Nakano, Chol-Jun Kwak, Kiwako Fujii, Kenji Ikemura, Aiko Satake, Mamoru Ohkita, Masanori Takaoka, Yoshiko Ono, Masaaki Nakai, Namino Tomimori, Yoshinobu Kiso, and Yasuo Matsumura |
| Sirius - Sesamin Metabolites Induce an Endothelial Nitric Oxide-Dependent Vasorelaxation through Their Antioxidative Property-Independent Mechanisms: Possible Involvement of the Metabolites in the Antihypertensive Effect of Sesamin |
| Journal of Pharmacology And Experimental Therapeutics JPET 318:328-335, 2006 |
| George Hsiao, Yi-Cheng Chen, Jiing-Han Lin, Kuang-Hung Lin, Duen-Suey Chou, Chien-Huang Lin, Joen-Rong Sheu |
| Orion - Inhibitory Mechanisms of Tetramethylpyrazine in Middle Cerebral Artery Occlusion (MCAO)-Induced Focal Cerebral Ischemia in Rats |
| Planta Med 2006, 72: 411-417 |
| Atsushi Nakajima, Kyoko Ueda, Masanori Takaoka, Yoshiko Yoshimi, and Yasuo Matsumura |
| Sirius - Opposite Effects of Pre- and Postischemic Treatments with Nitric Oxide Donor on Ischemia/Reperfusion-Induced Renal Injury |
| JPET 316:1038-1046, 2006 |
| Fujii A, Nakano D, Katsuragi M, Ohkita M, Takaoka M, Ohno Y, Matsumura Y. |
| Sirius - Role of gp91phox-containing NADPH oxidase in the deoxycorticosterone acetate-salt-induced hypertension |
| Eur J Pharmacol. 2006 Dec 15,552(1-3):131-4. |
| Rolando J.J. Ramirez, Carl A. Hubel, Jacqueline Novak, Jennifer R. DiCianno, Valerian E. Kagan, Robin E. Gandley |
| FB14 - Moderate Ascorbate Deficiency Increases Myogenic Tone of Arteries From Pregnant but Not Virgin Ascorbate?Dependent Rats |
| Hypertension 2006, 47, 454-460 |
| Shu-Ying Chen1, George Hsiao2, Hwong-Ru Hwang3, Pao-Yun Cheng4 & Yen-Mei Lee4 |
| Orion - Tetramethylpyrazine induces heme oxygenase-1 expression and attenuates myocardial ischemia/reperfusion injury in rats |
| Journal of Biomedical Science (2006) 13:731?740 |
| Ryszawa N, Kawczynska-Drozdz A, Pryjma J, Czesnikiewicz-Guzik M, Adamek-Guzik T, Naruszewicz M, Korbut R, Guzik TJ. |
| FB12 - Effects of novel plant antioxidants on platelet superoxide production and aggregation in atherosclerosis. |
| J Physiol Pharmacol. 2006 Dec,57(4):611-26. |
| Chai, Hong MD, PhD, Yang, Hui MD, PhD, Yan, Shaoyu PhD, Li, Min PhD, Lin, Peter H MD, Lumsden, Alan B MD, Yao, Qizhi MD, PhD, Chen, Changyi MD, PhD |
| Sirius - Effects of 5 HIV Protease Inhibitors on Vasomotor Function and Superoxide Anion Production in Porcine Coronary Arteries. |
| JAIDS Journal of Acquired Immune Deficiency Syndromes. 40(1):12-19, September 1, 2005. |
| Chao-Hung Wang, Shu-Hong Li, Richard D. Weisel, Paul W. M. Fedak, Agnes Hung, Ren-Ke Li, Vivek Rao, Keith Hyland, Wen-Jin Cherng, Lee Errett, Yves Leclerc, Daniel Bonneau, David A. Latter and Subodh Verma |
| FB12 - Tetrahydrobiopterin deficiency exaggerates intimal hyperplasia after vascular injury |
| Am J Physiol Regul Integr Comp Physiol 289: R299-R304, 2005. |
| Sebastian G. Braun, Andreas Meyer, Otto Holst, Alfred Puehler, and Karsten Niehaus |
| Sirius - Characterization of the Xanthomonas campestris pv. campestris Lipopolysaccharide Substructures Essential for Elicitation of an Oxidative Burst in Tobacco Cells |
| MPMI Vol. 18, No. 7, 2005, pp. 674-681. 2005 |
| Young M. Kim, Tomasz J. Guzik, Yin Hua Zhang, Mei Hua Zhang, Hassan Kattach, Chandi Ratnatunga, Ravi Pillai, Keith M. Channon, Barbara Casadei |
| FB12 - A Myocardial Nox2 Containing NAD(P)H Oxidase Contributes to Oxidative Stress in Human Atrial Fibrillation |
| Circ. Res. 2005,97,629-636 |
| Zhou W, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C. |
| Sirius - Ginsenoside Rb1 blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries. |
| J Vasc Surg. 2005 May, 41(5):861-8. |
| ANA FORTUNO, OSCAR BELOQUI, GORKA SAN JOSE, MARIA U MORENO, GUILLERMO ZALBA and JAVIER DIEZ |
| Sirius - Increased phagocytic nicotinamide adenine dinucleotide phosphate oxidase?dependent superoxide production in patients with early chronic kidney disease |
| Kidney International (2005) 68, S71?S75 |
| Brian S Conklin, Weiping Fu, Peter H Lin, Alan B Lumsden, Qizhi Yao and Changyi Chen |
| Sirius - HIV protease inhibitor ritonavir decreases endothelium-dependent vasorelaxation and increases superoxide in porcine arteries |
| Cardiovascular Research 2004 63(1):168-175 |
| A. Yorek, L. J. Coppey, J. S. Gellett, E. P. Davidson, and D. D. Lund |
| FB12 - Effect of Fidarestat and alpha-Lipoic Acid on Diabetes-Induced Epineurial Arteriole Vascular Dysfunction |
| Experimental Diab. Res., 5:123-135, 2004 |
| Spencer TA, Chai H, Fu W, Ramaswami G, Cox MW, Conklin BS, Lin PH, Lumsden AB, Yao Q, Chen C. |
| Sirius - Estrogen blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries |
| Journal of Surgical Research, Volume 118, Issue 1, 1 May 2004, Pages 83-90 |
| Fortuno, Ana, Olivan, Sara, Beloqui, Oscar, San Jose, Gorka, Moreno, Maria U, Diez, Javier, Zalba, Guillermo |
| Sirius - Association of increased phagocytic NADPH oxidase-dependent superoxide production with diminished nitric oxide generation in essential hypertension |
| Journal of Hypertension: November 2004 - Volume 22 - Issue 11 - pp 2169-2175 |
| Daniel Lei, Chiu-Po Chan, Ying-Jan Wang, Tong-Mei Wang, Bor-Ru Lin, Chun-Hsun Huang, Jang-Jaer Lee, Hsin-Ming Chen, Jiiang-Huei Jeng and Mei-Chi Chang |
| Orion - Antioxidative and Antiplatelet Effects of Aqueous Inflorescence Piper betle Extract |
| J. Agric. Food Chem., 2003, 51 (7), pp 2083?2088 |
| Tomasz J. Guzik, Nick E.J West, Ravi Pillai, David P. Taggart, Keith M. Channon |
| FB12 - Nitric Oxide Modulates Superoxide Release and Peroxynitrite Formation in Human Blood Vessels |
| Hypertension. 2002,39:1088-1094. |
| Gary E. McVeigh, MD, PhD, Paul Hamilton, BSc, Martin Wilson, BSc, Colm G. Hanratty, MD, William J. Leahey, BSc, Adrian B. Devine, BSc, David G. Morgan, MRCP, Lana J. Dixon, MRCP and Lawrence T. McGrath, PhD |
| Sirius - Platelet Nitric Oxide and Superoxide Release During the Development of Nitrate Tolerance |
| Circulation. 2002, 106:208 |
| Francesco Cosentino, Jane E. Barker, Michael P. Brand, Simon J. Heales, Ernst R. Werner, John R. Tippins, Nick West, Keith M. Channon, Massimo Volpe, Thomas F. Luescher |
| FB12 - Reactive Oxygen Species Mediate Endothelium-Dependent Relaxations in Tetrahydrobiopterin-Deficient Mice |
| Arterioscler Thromb Vasc Biol. 2001,21:496-502. |
| Meyer A, Puehler A, Niehaus K. |
| Sirius - The lipopolysaccharides of the phytopathogen Xanthomonas campestris pv. campestris induce an oxidative burst reaction in cell cultures of Nicotiana tabacum. |
| Planta. 2001 Jun, 213(2):214-22. |
Luminol-enhanced chemiluminescence
Miscellaneous
| Mitsuteru Natsuizaka, Shinya Ohashi Gabrielle S. Wong, Azal Ahmadi, Ross A. Kalman, Daniela Budo, Andres J. Klein-Szanto, Meenhard Herlyn, J. Alan Diehl and Hiroshi Nakagawa |
| Orion - Insulin-like growth factor-binding protein-3 promotes transforming growth factor-?1-mediated epithelial-to-mesenchymal transition and motility in transformed human esophageal cells |
| Carcinogenesis 2010 31(8):1344-1353 |
| Talat Nasim Dr and Richard Trembath Prof. |
| Orion - Efficiency of protein-protein interactions in mammalian cells determined by a dual-light assay |
| Nature Protocols 2007/06/28 |
| Shinichi Nakamura, Mitsuhiro Wada, Brian L. Crabtree, Patricia M. Reeves, John H. Montgomery, H. Joseph Byrd, Shiro Harada, Naotaka Kuroda and Kenichiro Nakashima |
| Sirius - A sensitive semi-micro column HPLC method with peroxyoxalate chemiluminescence detection and column switching for determination of MDMA-related compounds in hair |
| Analytical and Bioanalytical Chemistry Volume 387, Number 6 / 03/2007, 1983-1990 |
| Li Zhang, Michele DeRider, Melissa A. McCornack, Shu-chuan Jao, Nancy Isern, Traci Ness, Richard Moyer, and Patricia J. LiWang |
| Orion - Solution structure of the complex between poxvirus-encoded CC chemokine inhibitor vCCI and human MIP-1beta |
| PNAS September 19, 2006 vol. 103 no. 38 13985-13990 |
| Javorina Milosevic, Sigrid C. Schwarz, Knut Krohn, Monika Poppe, Alexander Storch, Johannes Schwarz |
| Sirius - Low atmospheric oxygen avoids maturation, senescence and cell death of murine mesencephalic neural precursors |
| Journal of Neurochemistry, 2005, 92, 718-729 |
| Yunlei Yang, Wooping Ge, Yiren Chen, Zhijun Zhang, Wanhua Shen, Chienping Wu, Muming Poo, and Shumin Duan |
| Sirius - Contribution of astrocytes to hippocampal long-term potentiation through release of D-serine |
| PNAS, December 9, 2003, vol. 100, no. 25, 15194-15199 |
| Steven W. Wilhelm, Jennifer M. DeBruyn, Osnat Gillor, Michael R. Twiss Kasey Livingston, Richard A. Bourbonniere, Lisa D. Pickell, Charles G. Trick, Amanda L. Dean, R. Michael L. McKay |
| FB14 - Effect of phosphorus amendments on present day plankton communities in pelagic Lake Erie |
| Aquat Microb Ecol Vol. 32: 275?285, 2003 |
MycoAlert
NADPH-Oxidase
| Sophie Van Linthout, Frank Spillmann, Mario Lorenz, Marco Meloni, Frank Jacobs, Marina Egorova, Verena Stangl, Bart De Geest, Heinz-Peter Schultheiss, Carsten Tschoepe |
| Sirius - Vascular-Protective Effects of High-Density Lipoprotein Include the Downregulation of the Angiotensin II Type 1 Receptor |
| Hypertension 2009, 53, 682-687 |
| Alvaro Yogi, Chantal Mercure, Joshuah Touyz, Glaucia E. Callera, Augusto C.I. Montezano, Anna B. Aranha, Rita C. Tostes, Timothy Reudelhuber, Rhian M. Touyz |
| Orion - Renal Redox-Sensitive Signaling, but Not Blood Pressure, Is Attenuated by Nox1 Knockout in Angiotensin II?Dependent Chronic Hypertension |
| Hypertension: Volume 51(2, Part 2) February 2008pp 500-506 |
| Manesh Thomas, MD, Dan Gavrila, MD, Michael L. McCormick, PhD, Francis J. Miller, Jr, MD, Alan Daugherty, PhD, DSc, Lisa A. Cassis, PhD, Kevin C. Dellsperger, MD, PhD, Neal L. Weintraub, MD |
| FB12 - Deletion of p47phox Attenuates Angiotensin II?Induced Abdominal Aortic Aneurysm Formation in Apolipoprotein E?Deficient Mice |
| (Circulation. 2006,114:404-413.) |
SEAP Reporter Assay
| Brooke Morriswood, Grigory Ryzhakov, Claudia Puri, Susan D. Arden, Rhys Roberts, Calliope Dendrou, John Kendrick-Jones, and Folma Buss |
| Orion - T6BP and NDP52 are myosin VI binding partners with potential roles in cytokine signalling and cell adhesion |
| Journal of Cell Science 120, 2574-2585 (2007) |
| Claire L. Warner, Abigail Stewart, J.Paul Luzio, Karen P. Steel, Richard T. Libby, John Kendrick-Jones and Folma Buss |
| Orion - Loss of myosin VI reduces secretion and the size of the Golgi in fibroblasts from Snell's waltzer mice |
| The EMBO Journal (2003) 22, 569-579 |
Toxicity and Mutagenicity
| Ewa Chec & Beata Podgorska & Grzegorz Wegrzyn |
| Sirius - Comparison of the use of mussels and semipermeable membrane devices for monitoring and assessment of accumulation of mutagenic pollutants in marine environment in combination with a novel microbiological mutagenicity assay |
| Environ Monit Assess (2008) 140:83-90 |
| Beata Podgorska, Ksenia Pazdro, Grzegorz Wegrzyn |
| Sirius - The use of the Vibrio harveyi luminescence mutagenicity assay as a rapid test for preliminary assessment of mutagenic pollution of marine sediments |
| J Appl Genet 48(4), 2007, pp. 409-412 |
| Natalia V. Ivanikova, R. Michael L. McKay, George S. Bullerjahn and Robert W. Sterner |
| FB14 - NITRATE UTILIZATION BY PHYTOPLANKTON IN LAKE SUPERIOR IS IMPAIRED BY LOW NUTRIENT (P, Fe) AVAILABILITY AND SEASONAL LIGHT LIMITATION ? A CYANOBACTERIAL BIOREPORTER STUDY |
| Journal of Phycology Volume 43 Issue 3, Pages 475 - 484 |
| John D. Gordon, Andrew C. Chu, Michael D. Chu, Cynthia Matherly, Michael S. Denison, Guerry Grune and George C. Clark |
| Orion - ESTROGENIC POTENCY OF MANY POPULAR SUNCREENS AND ITS NONACTIVE COMPONENTS DETECTED USING THE LUMI-CELL ER BIOASSAY |
| ISPAC - General, Dioxin 2005, no.1145, p. 2685 - 2689 |
| Natalia V. Ivanikova, R. Michael L. McKay, and George S. Bullerjahn |
| FB14 - Construction and characterization of a cyanobacterial bioreporter capable of assessing nitrate assimilatory capacity in freshwaters |
| Limnol. Oceanogr.: Methods 3, 2005, 86?93 |
| Perry LL, Bright NG, Carroll RJ Jr, Scott MC, Allen MS, Applegate BM. |
| FB14 - Molecular characterization of autoinduction of bioluminescence in the Microtox indicator strain Vibrio fischeri ATCC 49387. |
| Can J Microbiol. 2005 Jul, 51(7):549-57. |
Tumor Chemosensitivity Assay
| Selma Ugurel, Dirk Schadendorf Claudia Pfohler, Karsten Neuber, Adina Thoelke, Jens Ulrich, Axel Hauschild, Konstanze Spieth, Martin Kaatz, Werner Rittgen, Stefan Delorme, Wolfgang Tilgen, and Uwe Reinhold |
| MPL1 - In vitro Drug Sensitivity Predicts Response and Survival after Individualized Sensitivity-Directed Chemotherapy in Metastatic Melanoma: A Multicenter Phase II Trial of the Dermatologic Cooperative Oncology Group |
| Clinical Cancer Research Vol. 12, 5454-5463, September 15, 2006 |
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